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Explain the rapid patterned advance of clinical symptoms following introduction of superantigen compared with the delay stylish apparent responses to conventional antigen = this is because a vast quantity of cytokines ar produced in the presence of the superantigen, and they intercalate with the mhc ii and t-cell receptor.
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What kind of pathogens can cause HLA selection?
The potential of pathogens to drive HLA selection is suggested through investigations of emerging infectious diseases, such as HIV; in HIV infection, HLA class I allele heterozygosity, as opposed to homozygosity, correlates with delayed disease progression 6.
How are HLA genes linked to human diseases?
HLA gene variation was first linked to human disease with the discovery of the association between HLA-B and Hodgkin lymphoma 1. Since then, the MHC has been established as the region of the genome that is associated with the greatest number of human diseases 2.
What are the rules of the HLA interaction?
One model proposes that the HLA–peptide–TCR interactions that underpin self and non-self discrimination are guided by a set of rules that are perturbed in immunopathology.
Why is the specificity of HLA so important?
The specificity of HLA–peptide–TCR tripartite interactions is fundamental in enabling the adaptive immune system to mount an efficient and appropriate response to counteract infection and malignancy while maintaining self tolerance and preventing autoimmune disease.
Last Update: Oct 2021
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